Fraction of total gene sequences that are shared with other organism groups

Range prokaryotes 23%: non-animal eukaryotes (protists, fungi, and plants) 29%: nonchordate animals 27 %
Organism Mouse Mus musculus
Reference Gerhart J, Kirschner M. The theory of facilitated variation. Proc Natl Acad Sci U S A. 2007 May 15 104 Suppl 1: 8582-9 DOI: 10.1073/pnas.0701035104 p.8584 left column 3rd paragraphPubMed ID17494755
Primary Source [8] Mouse Genome Sequencing Consortium, Waterston RH et al., Initial sequencing and comparative analysis of the mouse genome. Nature. 2002 Dec 5 420(6915):520-62 DOI: 10.1038/nature01262PubMed ID12466850
Method Primary source abstract: "Here, [investigators] report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. [They] also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences."
Comments P.8584 left column 3rd paragraph: "Recent genome analysis has brought quantification to the impressions about conservation. More than 80 metazoan genomes have now been sequenced, and a typical case is the mouse (primary source). Of its total set of gene sequences, 23% are shared with prokaryotes, a further 29% are shared with non-animal eukaryotes (protists, fungi, and plants), and a further 27% are shared with nonchordate animals. Thus, 79% of mouse genes retain pre-Cambrian sequences. Reciprocally stated, only 21% of its functional components are unique to chordates, much less vertebrates, mammals, or mice."
Entered by Uri M
ID 117010