Intracellular regulation of intrinsically disordered proteins (IDPs) and ordered proteins

Range Table - link
Organism Eukaryotes
Reference Theillet FX et al., Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev. 2014 Jul 9 114(13):6661-714. doi: 10.1021/cr400695p p.6672 table 1PubMed ID24901537
Primary Source [252] Gsponer J, Futschik ME, Teichmann SA, Babu MM. Tight regulation of unstructured proteins: from transcript synthesis to protein degradation. Science. 2008 Nov 28322(5906):1365-8. doi: 10.1126/science.1163581 [253] Edwards YJ, Lobley AE, Pentony MM, Jones DT. Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data. Genome Biol. 200910(5):R50. doi: 10.1186/gb-2009-10-5-r50PubMed ID19039133, 19432952
Comments P. 6672 left column bottom paragraph: "Low abundance mRNAs encode disordered proteins involved in organ development and differentiation (primary source 253). In another study in E. coli, the authors found a weak, positive correlation between intrinsic disorder, mRNA expression levels and predicted protein abundance (ref 254). Although bacteria have fewer disordered proteins in their proteomes (∼5%) than higher eukaryotes (∼30-50%), their prominence in copius cellular factors such as ribosomal proteins, transcriptional regulators and chaperones (primary source 253) renders IDP mRNAs more abundant than transcripts of folded proteins. The Babu group also investigated the synthesis and degradation rates of IDP transcripts and compared them to the rates of ordered proteins (Table 1)(primary source 252)." P.6674 left column bottom paragraph: "So far, [investigators] discussed in vitro aspects of proteolytic processing. How do these considerations apply to the degradation of ordered and disordered proteins in vivo? The Babu group used different data sets reporting on protein half-life in a proteome-wide fashion to investigate differences in abundance, stability and degradation of ordered versus disordered proteins (Table 1)(primary source 252)." For organisms studied, see notes 'a' and 'b' beneath table
Entered by Uri M
ID 116044