Fraction of proteome that is membrane proteins

Range 31% C. elegans: 21% E. coli: 20% D. melanogaster %
Organism Eukaryotes
Reference Almén MS, Nordström KJ, Fredriksson R, Schiöth HB. Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin. BMC Biol. 2009 Aug 13 7: 50. p.2/14 left column top paragraphPubMed ID19678920
Primary Source Krogh A, Larsson B, von Heijne G, Sonnhammer EL. Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol. 2001 Jan 19 305(3):567-80.PubMed ID11152613
Method The membrane topology prediction method TMHMM (TransMembrane prediction using Hidden Markov Models) was applied on a number of proteomes from different species to estimate the membrane protein content
Comments Primary source abstract:"Based on these predictions, [investigators] estimate that 20-30 % of all genes in most genomes encode membrane proteins, which is in agreement with previous estimates."
Entered by Uri M
ID 106431