| Value |
78.4
unitless
|
| Organism |
Generic |
| Reference |
Theillet FX et al., Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev. 2014 Jul 9 114(13):6661-714. doi: 10.1021/cr400695p p.6664 right column 2nd paragraphPubMed ID24901537
|
| Primary Source |
[77] Endicott JA, Noble ME, Johnson LN. The structural basis for control of eukaryotic protein kinases. Annu Rev Biochem. 2012 81: 587-613. doi: 10.1146/annurev-biochem-052410-090317PubMed ID22482904
|
| Comments |
P.6664 right column 2nd paragraph: "Ions and charged metabolites contribute to the dielectric properties of the intracellular environment. The static dielectric constant of pure water is 78.4 at 25 °C (primary source), but dissolved ions can decrease this value substantially due to the tendency of water molecules to align with local electric fields caused by nearby ions (ref 78)... Based on measurements by Hasted et al., [investigators] estimate that in physiological solutions the dielectric constant of water would be reduced by only ∼2 units (i.e., to ∼76) primarily because of K+: given the complexity of the intracellular environment it is questionable whether this estimate is accurate." |
| Entered by |
Uri M |
| ID |
115815 |