| Range |
~1 %
|
| Organism |
Bacteria Escherichia coli |
| Reference |
Lydia Robert, Jean Ollion, Jerome Robert, Xiaohu Song, Ivan Matic, and Marina Elez, Mutation dynamics and fitness effects followed in single cells, Science 16 Mar 2018:
Vol. 359, Issue 6381, pp. 1283-1286
DOI: 10.1126/science.aan0797 p.1285 left column bottom paragraph |
| Method |
P.1285 left column bottom paragraph: "To further disentangle age- and mutation-related mortality, [investigators] performed a µMA [microfluidic mutation accumulation] experiment using the strain pMQ, which has increased proofreading deficiency compared with MF1 (ref 21). pMQ cells died rapidly,
and their survival decreased exponentially (Fig.4B, right, and fig. S11)." |
| Comments |
P.1285 left column bottom paragraph: "These analyses [see Measurement
Method section] demonstrate that lethal mutations occur at a constant rate in µMA, independently of previously acquired mutations, and that ~1% of mutations are lethal." |
| Entered by |
Uri M |
| ID |
114862 |