Ratio between pantothenate production and pantothenate phosphorylation

Value 15 times more pantothenate produced than phsophorylated
Organism Bacteria Escherichia coli
Reference Vallari DS, Jackowski S. Biosynthesis and degradation both contribute to the regulation of coenzyme A content in Escherichia coli. J Bacteriol. 1988 Sep170(9):3961-6 p.3961 left column top paragraphPubMed ID2842294
Primary Source [6] Jackowski, S., and C. 0. Rock. 1981. Regulation of coenzyme A biosynthesis. J. Bacteriol. 148: 926-932.PubMed ID6796563
Comments P.3961 left column top paragraph: "Metabolic labeling experiments illustrate that the cellular CoA concentration fluctuates depending on the carbon source and growth state of Escherichia coli (refs 8, 10, 18). The regulation of pantothenate kinase appears to be the most important determinant of the CoA biosynthetic rate since 15 times more pantothenate is produced than is phosphorylated (primary source), suggesting that a maximum of 25% of the catalytic capacity of the enzyme is expressed in normally growing cells (ref 18)."
Entered by Uri M
ID 114601