Growth, uptake, and production rates of seven E. coli strains in aerobic and anaerobic batch culture

Range Table - link
Organism Bacteria Escherichia coli
Reference Monk JM et al., Multi-omics Quantification of Species Variation of Escherichia coli Links Molecular Features with Strain Phenotypes. Cell Syst. 2016 Sep 28 3(3):238-251.e12. doi: 10.1016/j.cels.2016.08.013. p.240 table 1PubMed ID27667363
Method Abstract: "Here, [investigators] quantified strain-specific differences in seven widely used strains of E. coli (BL21, C, Crooks, DH5a, K-12 MG1655, K-12 W3110, and W) using genomics, phenomics, transcriptomics, and genome-scale modeling. Metabolic physiology and gene expression varied widely with downstream implications for productivity, product yield, and titer."
Comments P.239 right column bottom paragraph: "To assess growth dynamics and by-product secretion rates, phenotypic characterizations were performed in aerobic and anaerobic M9 minimal media (STAR Methods). Major differences were observed between the strains during exponential growth phase. Aerobically, the growth rates ranged from 0.61/h (W3110) to 0.97/h (W), with a mean growth rate of 0.80 ± 0.12/h, see Table 1." P.240 left column 2nd paragraph: "The rate of substrate consumption in the different strains (Table 1, Figure S3) also exhibited significant variation (a 1.9- and 3.6-fold difference aerobically and anaerobically, respectively), a fact that has important implications for productivity and bioprocessing costs."
Entered by Uri M
ID 113215