| Range |
Figure - link
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| Organism |
Rodent |
| Reference |
Ke Z et al., Translation fidelity coevolves with longevity. Aging Cell. 2017 Jul 13. doi: 10.1111/acel.12628. p.2 figure 1PubMed ID28707419
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| Primary Source |
Tacutu R et al., Human Ageing Genomic Resources: integrated databases and tools for the biology and genetics of ageing. Nucleic Acids Res. 2013 Jan41(Database issue):D1027-33. doi: 10.1093/nar/gks1155PubMed ID23193293
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| Method |
P.2 right column 3rd paragraph: "To examine the role of translational fidelity in aging, [investigators] tested whether translational fidelity co-evolved with species maximum lifespan. [They] examined translation fidelity in rodent species with diverse maximum lifespan ranged from 4 to 32 years (Fig. 1). [They] found a strong correlation between the frequency of mistranslating the first and second codon positions and the maximum lifespan in 16 rodent species. This correlation remained significant after phylogenetic correction by the method of independent contrast, indicating that translation fidelity co-evolved with longevity. The fidelity of mistranslation at the third position and the misreading of a stop codon did not correlate with maximum lifespan, possibly due to the wobble effect at the third codon position, and to extremely low frequency of misreading the stop codon in all species. These results provide evidence that translation fidelity is an important factor in determining species lifespan." |
| Comments |
See note beneath figure |
| Entered by |
Uri M |
| ID |
113881 |