| Comments |
P.4552 left column bottom paragraph: "Glutathione (GSH) is a very important tripeptide present in quantity ranging from 1 to 10 mM in all cellular types. GSH is involved in a multitude of cellular processes, including detoxification of xenobiotics, antioxidant defense, proliferation, and apoptosis. Deficiency in GSH contributes to oxidative stress, which plays a key role in aging and in the development of many human diseases, including neurodegenerative diseases, liver diseases, diabetes, cystic fibrosis, AIDS, heart attack, and cancers. GSH is synthesized in the cytosol by two enzymes, the γ-glutamylcysteine synthetase (γ-GCS),[ref 3] considered as the rate-limiting enzyme of the pathway, and the glutathione synthetase (see Fig. 1)." See BNID 113869 |