| Range |
lifespan 30-50: size and total cellularity 3,000: number of cell divisions throughout life 10^5 unitless
|
| Organism |
Mammals |
| Reference |
Krueger A, Ziętara N, Łyszkiewicz M. T Cell Development by the Numbers. Trends Immunol. 2017 Feb38(2):128-139. doi: 10.1016/j.it.2016.10.007 p.135 bottom paragraphPubMed ID27842955
|
| Primary Source |
[78] A. Rangarajan, R.A. Weinberg Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice Nat. Rev. Cancer, 3 (2003), pp. 952-959 doi: 10.1038/nrc1235PubMed ID14737125
|
| Comments |
P.135 bottom paragraph: "On an organismal level, humans and mice differ in lifespan by a factor of 30–50, size and total cellularity by a factor of 3000, and number of cell divisions throughout life by a factor of 10^5 [primary source]. Furthermore, murine cells have a higher basal metabolic rate and display profound differences in telomere biology, which directly affect the aging process [refs 15,79]. It remains an open question whether these complex differences can be incorporated into computational models attempting to quantify human T cell development." |
| Entered by |
Uri M |
| ID |
113831 |