| Range |
mice WX 2.81±1.14: rat weighted arithmetic mean 2.37: human WX 3.48±1.55 days
|
| Organism |
Mammals |
| Reference |
Darwich AS, Aslam U, Ashcroft DM, Rostami-Hodjegan A. Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans. Drug Metab Dispos. 2014 Dec42(12):2016-22. doi: 10.1124/dmd.114.058404 abstractPubMed ID25233858
|
| Method |
Abstract: "Current physiologically based pharmacokinetic (PBPK) models consider enzyme and enterocyte recovery as a lumped first-order rate. An assessment of enterocyte turnover would enable enzyme and enterocyte renewal to be modeled more mechanistically. A literature review together with statistical analysis was employed to establish enterocyte turnover in human and preclinical species." |
| Comments |
Abstract: "In mice, the geometric weighted combined mean (WX) enterocyte turnover was 2.81 ± 1.14 days (n = 169). In rats, the weighted arithmetic mean enterocyte turnover was determined to be 2.37 days (n = 501). Humans exhibited a geometric WX enterocyte turnover of 3.48 ± 1.55 days for the gastrointestinal epithelia (n = 265), displaying comparable turnover to that of cytochrome P450 enzymes in vitro (0.96-4.33 days)." P.2018 left column bottom paragraph: "The literature search of enterocyte turnover in healthy adult subjects of preclinical species identified a total of 68 studies (n subjects = 1337). In the rat, 24 studies consisting of 501 subjects were identified (Supplemental Table 1), in which the arithmetic WX [weighted mean] GI [gastrointestinal] enterocyte
turnover was determined to be 2.37 days." P.2018 right column bottom paragraph: "In the mouse, a total of 31 studies consisting of 651 healthy adult mice was identified reporting the enterocyte turnover in the small intestinal epithelia (Supplemental Table 2). The geometric WX enterocyte turnover for the GI tract was 2.81 (±1.14, n = 169 mice) days." P.2020 right column bottom paragraph: "The human enterocyte turnover, as determined in this analysis
(approximately 3.48 days), suggests the GI epithelia to display a comparable rate of renewal to that of the P450 enzymes as determined in vitro, in which Yang et al. (2008) found reported P450
turnover to vary between 0.96 and 4.33 days (BNID 113695)." |
| Entered by |
Uri M |
| ID |
113694 |