| Range |
200 to 400 Days
|
| Organism |
Mammals |
| Reference |
Malato Y et al., Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest. 2011 Dec121(12):4850-60. doi: 10.1172/JCI59261. p.4853 right column 2nd paragraphPubMed ID22105172
|
| Primary Source |
Magami et al., Cell proliferation and renewal of normal hepatocytes and bile duct cells in adult mouse liver. Liver. 2002 Oct22(5):419-25. AND Macdonald RA. "Lifespan" of liver cells. Autoradio-graphic study using tritiated thymidine in normal, cirrhotic, and partially hepatectomized rats. Arch Intern Med. 1961 Mar107: 335-43.PubMed ID12390477, 13764742
|
| Comments |
"Hepatocyte turnover in the normal adult liver is
slow — the life span of a hepatocyte ranges from 200
to 400 days in mice (1st primary source) and rats (2nd primary source)." For lifespan of at least 300-400 days see PMID 11287642 p.4584 right column bottom paragraph |
| Entered by |
Uri M |
| ID |
109233 |