Life span of hepatocyte in mice and rats

Range 200 to 400 Days
Organism Mammals
Reference Malato Y et al., Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest. 2011 Dec121(12):4850-60. doi: 10.1172/JCI59261. p.4853 right column 2nd paragraphPubMed ID22105172
Primary Source Magami et al., Cell proliferation and renewal of normal hepatocytes and bile duct cells in adult mouse liver. Liver. 2002 Oct22(5):419-25. AND Macdonald RA. "Lifespan" of liver cells. Autoradio-graphic study using tritiated thymidine in normal, cirrhotic, and partially hepatectomized rats. Arch Intern Med. 1961 Mar107: 335-43.PubMed ID12390477, 13764742
Comments "Hepatocyte turnover in the normal adult liver is slow — the life span of a hepatocyte ranges from 200 to 400 days in mice (1st primary source) and rats (2nd primary source)." For lifespan of at least 300-400 days see PMID 11287642 p.4584 right column bottom paragraph
Entered by Uri M
ID 109233