Enterocyte turnover in the small intestine

Range Table - link days
Organism Rat Rattus norvegicus
Reference Darwich AS, Aslam U, Ashcroft DM, Rostami-Hodjegan A. Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans. Drug Metab Dispos. 2014 Dec42(12):2016-22. doi: 10.1124/dmd.114.058404 supplementary data pp.8-12 table 1PubMed ID25233858
Primary Source See pointers to refs in right column of table
Method Abstract: "Current physiologically based pharmacokinetic (PBPK) models consider enzyme and enterocyte recovery as a lumped first-order rate. An assessment of enterocyte turnover would enable enzyme and enterocyte renewal to be modeled more mechanistically. A literature review together with statistical analysis was employed to establish enterocyte turnover in human and preclinical species." See "Method" column in table
Comments P.2018 left column bottom paragraph: "The literature search of enterocyte turnover in healthy adult subjects of preclinical species identified a total of 68 studies (n subjects = 1337). In the rat, 24 studies consisting of 501 subjects were identified (Supplemental Table 1), in which the arithmetic WX [weighted mean] GI [gastrointestinal] enterocyte turnover was determined to be 2.37 days."
Entered by Uri M
ID 113697