| Comments |
P.410 left column bottom paragraph: "This pattern is characteristic for the fact that under the circumstances of a myeloablative radiation dose the pools of proliferating and differentiating cells as well as the stem cell pool is essentially eradicated. The blood cell degenerative pattern reflects the fact that granulocytes and the maturing-only pool are initially not affected by these dose levels and mature out to replace for a period of about 4 days the blood pool of granulocytes. Once the transit time of the maturing only pool is elapsed, no further cells appear in the maturation-only pool, because of the destruction of the proliferating/differentiating and stem cell pools. As far as the platelets is concerned, the pool of megakaryocytes is apparently damaged together with the stem cell pool in such a way that the platelets that are still available are released into the blood but are not replaced by newly formed megakaryocytes and platelets and therefore they disappear from the blood within 10 days (which is the maximum life-span of a platelet)." |