| Range |
total blood cell production rate ~490E9 Figure link cells/day
|
| Organism |
Human Homo sapiens |
| Reference |
Fliedner TM, Graessle D, Paulsen C, Reimers K. Structure and function of bone marrow hemopoiesis: mechanisms of response to ionizing radiation exposure. Cancer Biother Radiopharm. 2002 Aug17(4):405-26. doi:10.1089/108497802760363204. p.406 right column bottom paragraph & p.407 figure 1PubMed ID12396705
|
| Primary Source |
[6] Fliedner TM, Steinbach KH and Hoelzer D. Adaptation to environmental change: the role of cell-renewal systems. In: Finckh ES, editor. The Effects of Environment on Cells and Tissues. Amsterdam: Excerpta Medica, 1976 |
| Comments |
P.406 right column bottom paragraph: "In order to appreciate the functionality of hematopoietic homeostasis, it is of importance to analyze the turnover kinetics of the various blood cell types under normal conditions. Each cell type in the blood is characterized by a life-expectancy
given in Figure 1. It appears to be a characteristic property of hemopoietic cell renewal to achieve—whenever feasible and possible—a constant number of the different blood elements per unit volume. Under physiological conditions, the rate of cells entering the blood (Kin) equals the rate of leaving the peripheral blood (Kout). Thus, the turnover per day varies considerably between the major cell types, but is in the order of several to many billions per day. If one considers the annual cumulative cell production, one can calculate a total blood cell production rate of about 490×10^9 cells per day or about 88 kg per year (primary source). The fact that a human being can live a normal life and is not “drowned” within his own cell waste is due to the fact that for each cell produced in the hemopoietic system, one cell is lost due to senescence or emigration in order to maintain a homeostatic equilibrium between production and removal." |
| Entered by |
Uri M |
| ID |
113413 |