Number of blood cells produced by hematopoietic cell compartment of bone marrow

Range ~5×10^11 cells/day
Organism Human Homo sapiens
Reference Vunjak-Novakovic G et al., Challenges in cardiac tissue engineering. Tissue Eng Part B Rev. 2010 Apr16(2):169-87. doi: 10.1089/ten.TEB.2009.0352. p.170 right column 4th paragraphPubMed ID19698068
Primary Source [21] Taichman RS. Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche. Blood. 2005 Apr 1 105(7):2631-9. DOI: 10.1182/blood-2004-06-2480 [22] Berardi AC, Wang A, Levine JD, Lopez P, Scadden DT. Functional isolation and characterization of human hematopoietic stem cells. Science. 1995 Jan 6 267(5194):104-8.PubMed ID15585658, 7528940
Comments P.170 right column 4th paragraph: "Bone marrow–derived adult stem cells: The discovery of circulating endothelial progenitor cells, (ref 18) their mobilization in response to ischemia, (ref 19) and their isolation from human bone marrow (ref 20) have stimulated translational research of the use of bone marrow–derived elements to regenerate ischemic myocardium. The bone marrow compartment can be subdivided into two interdependent spaces—the hematopoietic cell compartment and the stroma containing MSCs (mesenchymal stem cells). The hematopoietic compartment produces approximately 500 billion cells per day that use the bone marrow vasculature as a conduit to the systemic circulation (primary sources). The stroma is composed of fibroblasts, adipocytes, nerves, and the bone marrow’s vascular system that consists of a network of fenestrated, thin-walled vessels supported by the surrounding hematopoietic cells."
Entered by Uri M
ID 113199