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p.289 left column top paragraph: "Saccharomyces cerevisiae is one of the most intensively investigated model organisms in life sciences with a fully sequenced and annotated genome, and several full knockout and complementation plasmid libraries available for researchers. This unicellular eukaryote allowed to gain insight in basic cellular mechanisms such as DNA replication, cell cycle progression, protein turnover, vesicular trafficking, nutrient- or stress-induced signal transduction and mechanisms involved in longevity and cell death. Based on these studies, it became clear that key cellular processes are well conserved between yeast and humans. 31% of the yeast genes have a mammalian homologue and an additional 30% of yeast genes show domain similarity (primary source). Consistently, about 30% of the genes known to be involved in human diseases may have a yeast orthologue ( Botstein and Chervitz, 1997, Foury, 1997). Cell division machinery, cell polarity and cytoskeleton organization of the fission yeast Schizosaccharomyces pombe are even more closely related to the mammalian situation (Balasubramanian et al., 2004, Humphrey and Pearce, 2005)." |