Rate of collagen bundle area increase from birth to 6 weeks

Range ≈0.83 µm^2/day
Organism Mouse Mus musculus
Reference Rutenberg AD, Brown AI, Kreplak L. Uniform spatial distribution of collagen fibril radii within tendon implies local activation of pC-collagen at individual fibrils. Phys Biol. 2016 Aug 25 13(4):046008. doi: 10.1088/1478-3975/13/4/046008. p.3 right column 2nd paragraphPubMed ID27559989
Primary Source [3] Kalson N S, Lu Y, Taylor S H, Starborg T, Holmes D F and Kadler K E 2015 A structure-based extracellular matrix expansion mechanism of fibrous tissue growth eLife 4 e05958 doi: 10.7554/eLife.05958.PubMed ID25992598
Method Primary source abstract: "[Investigators] present a model for fibrous tissue growth based on 3D-electron microscopy of mouse tendon."
Comments P.3 right column 2nd paragraph: "[Investigators] can now check the quasi-static approximation underlying equation (1). For it to be valid [they] need the neglected term (δρ/δt) to be much smaller in magnitude than the incorporation rate s. Using the solution equation (2) to evaluate δρ/δt, the ratio of the terms is |δρ/δt|/s=d(πR^2)/dt/(4πDcol)≈1.0×10^-7, (8) where d(πR^2)/dt≈0.83µm^2/day is the rate of bundle area increase from birth to 6w [primary source]. [Investigators] see that the dimensionless ratio is vanishingly small, i.e. the quasi-static approximation was well justified. Fibrils and bundles grow slowly compared to diffusion timescales."
Entered by Uri M
ID 112908