Estimated rates of beneficial mutation in E. coli & RNA viruses
| Range | 1E-09 - 1E-08 1/genome/generation |
|---|---|
| Organism | Various |
| Reference | Perfeito L, Fernandes L, Mota C, Gordo I. Adaptive mutations in bacteria: high rate and small effects. Science. 2007 Aug 10 317(5839):813-5. DOI: 10.1126/science.1142284 p.813 right column top paragraphPubMed ID17690297 |
| Primary Source | [4] M. Imhof, C. Schlotterer, Fitness effects of advantageous mutations in evolving Escherichia coli populations. Proc. Natl. Acad. Sci. U.S.A. 98, 1113 (2001). DOI: 10.1073/pnas.98.3.1113 [5] R. Miralles, P. J. Gerrish, A. Moya, S. F. Elena, Clonal interference and the evolution of RNA viruses. Science 285, 1745 (1999). [16] Daniel E. Rozen, J.Arjan G.M. de Visser, Philip J. Gerrish, Fitness Effects of Fixed Beneficial Mutations in Microbial Populations, Current Biology Volume 12, Issue 12, 25 June 2002, Pages 1040–1045PubMed ID11158603, 10481012, 12123580 |
| Comments | P.813 right column top paragraph: "Current estimates for Ua [beneficial mutation rate] fall around 10^–9 to 10^–8 for RNA viruses and Escherichia coli (primary sources). A similar beneficial mutation rate was estimated for Pseudomonas fluorescens under adaptation to stressful conditions (ref 9). A caveat for all of these estimates is that they were obtained from populations with very large effective population size (Ne) and followed adaptation to a new environment under conditions in which clonal interference had a strong effect. This led to downward biased estimates of Ua. Here, [investigators] provide estimates for the genomic mutation rate for beneficial mutations in E. coli that are less biased by clonal interference." For E. coli beneficial mutation rate of 2E-05/genome/generation see BNID 112768 |
| Entered by | Uri M |
| ID | 112769 |