| Range |
0.002 %
|
| Organism |
Human Homo sapiens |
| Reference |
Jackson AL, Loeb LA. The mutation rate and cancer. Genetics. 1998 Apr148(4):1483-90. p.1484 left column bottom paragraphPubMed ID9560368
|
| Primary Source |
McNiece IK et al., Detection of a human CFC with a high proliferative potential. Blood. 1989 Aug 1 74(2):609-12.PubMed ID2665850
|
| Method |
Primary source abstract: "Colony forming cells (CFC) with high proliferative potential have been detected in nutrient agar cultures of human bone marrow cells containing recombinant human interleukin-3 (IL-3) and granulocyte macrophage colony stimulating factor (GM-CSF). These CFC were detected by the formation of large colonies with diameters greater than 0.5 mm and containing approximately 50,000 cells after 28 days incubation." |
| Comments |
P.1484 left column bottom paragraph: "In the absence of selection or clonal proliferation, one can estimate the number of spontaneous mutations that could accumulate in stem cells with the potential to proliferate into a tumor. Based on studies in human bone marrow, it has been estimated that only 0.002% of the cells can form colonies with high proliferative potential (primary source) and thus can operationally be considered as stem cells." |
| Entered by |
Uri M |
| ID |
112677 |