| Range |
Table - link
|
| Organism |
Human Homo sapiens |
| Reference |
Seshadri R, Kutlaca RJ, Trainor K, Matthews C, Morley AA. Mutation rate of normal and malignant human lymphocytes. Cancer Res. 1987 Jan 15 47(2):407-9. p.408 table 1PubMed ID3466691
|
| Primary Source |
See refs beneath table |
| Method |
Abstract: "The genetic stability of normal and neoplastic lymphocytes was compared by using base-line mutation frequency and mutation rate/cell generation. Mutations at the hypoxanthine-guanine phosphoribosyltransferase locus were studied by enumerating thioguanine-resistant cells in a clonogenic assay." |
| Comments |
P.407 left column 5th paragraph: "The following established leukemia and lymphoma cell lines were studied in the logarithmic phase of growth: two Burkitt's lymphoma B-cell lines, FMC-HU-1B and HRIK and JM (Jurkat), an acute lymphoblastic leukemia T-cell line. Human lymphocytes were obtained from peripheral blood samples of five healthy volunteer donors." P.408 left column top paragraph: "Table 1 shows the "spontaneous" mutation frequency in normal and malignant cells. In vivo mutation frequency in normal lymphocytes was estimated in 117 healthy normal individuals (previous data from Refs. 4 and 14) and in the 3 subjects in the present study. The 3 malignant cell lines had spontaneous in vitro mutation frequencies which were 10- to
1000-fold greater than the in vivo mutation frequency of normal
lymphocytes." |
| Entered by |
Uri M |
| ID |
112660 |