| Range |
Half-life of virus-producing CD4+ T cell 0.7 days: generation time of HIV-1 in vivo ~2 days days
|
| Organism |
HIV |
| Reference |
Markowitz M et al., A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo. J Virol. 2003 Apr77(8):5037-8. abstract & p.5038 table 1 Table - link PubMed ID12663814
|
| Method |
Abstract: "Mathematical models provide an understanding of in vivo replication kinetics of human immunodeficiency
virus type 1 (HIV-1). With a novel intervention designed for increased potency, [investigators] have more accurately deduced the half-lives of virus-producing CD4+ T cells, 0.7 day, and the generation time of HIV-1 in vivo, approximately 2 days, confirming the dynamic nature of HIV-1 replication." |
| Comments |
P.5037 right column 2nd paragraph: "Nine chronically HIV-1-infected individuals (Table 1) were treated with lopinavir-ritonavir (1,066 and 266 mg/day, respectively), efavirenz (600 mg/day), lamivudine (300 mg/day), and
tenofovir DF (300 mg/day)." P.5037 right column 3rd paragraph: "By using nonlinear regression analysis, [investigators] estimated δ [rate of
loss of productively infected CD4+ T cells] for each patient by fitting plasma viral load data to [their] published mathematical model (refs 4, 5), using a value for c [clearance rate constant of plasma
virions] of 23 day^-1 (ref 6) (Fig. 1). The best-fit values of δ ranged from 0.6 to 1.4 day^-1, with a mean of 1.0 day^-1. The latter value translates into a mean t1/2 of 0.7 day (Table 1), which is significantly shorter than [their] last estimate of 1.1 days (ref 4)." |
| Entered by |
Uri M |
| ID |
112646 |