Abstract
Mathematical models provide an understanding of in vivo replication kinetics of human immunodeficiency virus type 1 (HIV-1). With a novel intervention designed for increased potency, we have more accurately deduced the half-lives of virus-producing CD4(+) T cells, 0.7 day, and the generation time of HIV-1 in vivo, approximately 2 days, confirming the dynamic nature of HIV-1 replication.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-HIV Agents / therapeutic use*
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CD4 Lymphocyte Count
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CD4-Positive T-Lymphocytes / physiology*
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CD4-Positive T-Lymphocytes / virology
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HIV Infections / drug therapy*
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HIV Infections / virology
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HIV Protease Inhibitors / therapeutic use
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HIV-1 / physiology*
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Humans
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Models, Biological
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RNA, Viral / blood
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Reverse Transcriptase Inhibitors / therapeutic use*
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Virus Replication*
Substances
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Anti-HIV Agents
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HIV Protease Inhibitors
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RNA, Viral
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Reverse Transcriptase Inhibitors