Time for restoration of total hemoglobin mass (tHb) after donation [blood loss of approximately 550 mL]

Value 36 days Range: ±11 range: 20-59 days
Organism Human Homo sapiens
Reference Pottgiesser T et al., Recovery of hemoglobin mass after blood donation. Transfusion. 2008 Jul48(7):1390-7. doi: 10.1111/j.1537-2995.2008.01719.x. abstract, p.1393 left column 3rd paragraph, caption to fig.1 & right column top paragraphPubMed ID18466177
Method Abstract: "Study design and methods: The optimized CO rebreathing method was used for evaluation of tHb [total hemoglobin mass] before and after 1-unit (erythrocyte concentrate) standard blood donation in 29 male volunteers (30 +/- 10 years, 181 +/- 7 cm, 76.6 +/- 11.2 kg). Subsequently, tHb measurements were performed in regular intervals until one of two termination criteria was met."
Comments Abstract: "Results: After donation of approximately 550 mL of whole blood, the lost amount of tHb of 75 +/- 15 g (8.8 +/- 1.9%) was recovered after a mean of 36 +/- 11 days (range, 20-59 days)." P.1393 left column 3rd paragraph: "Recovery of tHb after blood donation: All test subjects remained healthy during the observation period. The tHb loss of 8.8 ± 1.9 percent (75 ± 15 g) caused by standard blood donation was regenerated after a mean interval of 36 ± 11 days (95% CI, 32-40 days range, 20-59 days Fig. 1)." P.1393 right column top paragraph: "Discussion: The main finding of this study is that tHb as a direct measure of the blood system is restored in a mean of 36 ± 11 days after international-standard whole-blood donation. The blood loss of approximately 550 mL accounted for 8.8 ± 1.9 percent of the baseline tHb corresponding to an absolute loss of 75 ± 15 g tHb."
Entered by Uri M
ID 112601