| Value |
0.07
%/day
|
| Organism |
Mouse Mus musculus |
| Reference |
Kushner JA. The role of aging upon β cell turnover. J Clin Invest. 2013 Mar123(3):990-5. doi: 10.1172/JCI64095. p.990 right column bottom paragraphPubMed ID23454762
|
| Primary Source |
[21] Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA. Very slow turnover of beta-cells in aged adult mice. Diabetes. 2005 54(9):2557–2567.PubMed ID16123343
|
| Method |
Primary source abstract:"To more accurately measure adult beta-cell turnover, [investigators] performed continuous long-term labeling of proliferating cells with the DNA precursor analog 5-bromo-2-deoxyuridine (BrdU) in 1-year-old mice." |
| Comments |
P.990 right column bottom paragraph:"Although rodent β cells have traditionally been thought to undergo frequent turnover, recent studies suggest that cell cycle entry of β cells may be severely limited in advanced age. A highly cited thymidine analog–labeling study by Finegood, Scaglia, and Bonner-Weir reported that β cells replicated every 1–3 months in young rats (BNID 112318). However, [investigators'] work reveals that β cell turnover declines markedly by 12 months of age in mice (approximately 0.07% cell turnover per day) (primary source). Minimal β cell proliferation has also been observed by other investigators in mice that were more than one year old (refs 22, 23)." Primary source abstract:"only 1 in approximately 1,400 adult beta-cells were found to undergo replication per day." |
| Entered by |
Uri M |
| ID |
112319 |