| Method |
P.376 left column 2nd paragraph:"The First World Cell Race (Maiuri et al., 2012), which gathered recordings of individual cell trajectories on 1D adhesive tracks for 54 different adherent cell types made available an unprecedented amount of data. [Investigators] performed a further analysis of this data and confirmed a clear positive correlation between the population averaged mean linear instantaneous cell speed and the population averaged persistence time at the level of all cell types (Figure 1A), despite their variety. To assess the robustness of this observation and check its validity at the level of single cell trajectories, [they] performed new experiments on two representative examples of migrating cell with either a mesenchymal migration mode (hTERT [human Telomerase reverse transcriptase]-immortalized retinal pigment epithelial cell line [RPE1]) or an amoeboid migration mode (immature bone marrow-derived mice dendritic cells [BMDC]), in various geometries (Figures S1 and S2 Movie S1): 1D adhesive tracks (Figure 1C), 1D microchannels (Figure 1D), 2D non-confined adhesive substrates (Figure 1E) and 2D confined substrates (Figure 1F)." |