| Range |
Table - link
|
| Organism |
Rat Rattus norvegicus |
| Reference |
Jasmin BJ, Lavoie PA, Gardiner PF. Fast axonal transport of labeled proteins in motoneurons of exercise-trained rats. Am J Physiol. 1988 Dec255(6 Pt 1):C731-6. p.C733 table 2PubMed ID2462358
|
| Method |
Abstract:"In this study, the fast orthograde axonal transport of radiolabeled proteins was measured to determine the effects of endurance-running training on transport velocity and amounts of transported proteins in rat sciatic motoneurons. Female rats were subjected to a progressive running-training program for 10-12 wk. Twenty-four hours after the last training session, rats underwent right L4-L5 dorsal root ganglionectomy. The next day, 20 microCi of [3H]leucine was injected bilaterally in the vicinity of the motoneuronal cell bodies supplying the sciatic nerve, to study axonal transport parameters." |
| Comments |
P.C733 right column top paragraph:"The velocity of transport must be calculated from the displacement data obtained at two time points to eliminate from the calculations the effects of factors independent of velocity (see below). Examination of constructed regression lines of distance over time for the sets of hypothetical animals showed that peak and average transport velocities (slopes of the regression equations)
were increased (P < 0.05) by 22 and 29%, respectively, only in the deafferented nerves of the trained rats as compared with those of control animals (Table 2). Backward extrapolation of the regression lines to zero distance indicates the time lag required for precursor uptake and protein synthesis and release into the axon. This delay represents cellular events independent of transport velocities but is included in displacement measures. The delay was found not to differ (P > 0.05) between the groups (Table 2)." |
| Entered by |
Uri M |
| ID |
112234 |