| Value |
16
nm
|
| Organism |
Eukaryotes |
| Reference |
Gennerich A, Vale RD. Walking the walk: how kinesin and dynein coordinate their steps. Curr Opin Cell Biol. 2009 Feb21(1):59-67. doi: 10.1016/j.ceb.2008.12.002. p.59 right column bottom paragraphPubMed ID19179063
|
| Primary Source |
A. Yildiz, M. Tomishige, R.D. Vale, P.R. Selvin Kinesin walks hand-over-hand Science, 303 (2004), pp. 676–678PubMed ID14684828
|
| Comments |
P.59 right column bottom paragraph:"Kinesin walks in a ‘hand-over-hand’ manner [e.g. [ref 10]], with each head taking alternating 16 nm ‘steps’ (Figure 2a) [primary source]. This mechanism requires tight coupling between the biochemical cycles of both heads so that the front head remains bound to the MT [microtubule] while the rear head detaches. A conformational change in the front head then moves the detached head forward. This conformational change most probably occurs in a ∼13 aa peptide that links the motor domain to the coiled-coil stalk called the neck linker (Figure 1a) [ref 21]." |
| Entered by |
Uri M |
| ID |
112203 |