Molecular mass of dynein

Value 1.2 MDa
Organism Eukaryotes
Reference Gennerich A, Vale RD. Walking the walk: how kinesin and dynein coordinate their steps. Curr Opin Cell Biol. 2009 Feb21(1):59-67. doi: 10.1016/ p.60 right column top paragraphPubMed ID19179063
Primary Source R.D. Vale The molecular motor toolbox for intracellular transport Cell, 112 (2003), pp. 467–480PubMed ID12600311
Comments P.60 right column top paragraph:"Unlike kinesin, relatively little is known about the molecular mechanism of dynein (Figure 1b). Dynein, which is a member of the AAA+ family (AAA: ATPase associated with various cellular activities), is involved in diverse processes in eukaryotic cells, such as spindle formation, chromosome segregation, and the trafficking of organelles and mRNA [ref 2]. Dynein is a large protein complex (1.2 MDa) composed of two identical heavy chains and several associated chains [primary source]." See Fu & Holzbaur 2014, PMID 24953741 p.568 box 2 1st paragraph:"Cytoplasmic dynein is the major minus-end-directed microtubule motor for organelle transport in eukaryotic cells. The enormous (∼1.5 MDa) dynein complex consists of two dynein heavy chains (DHC ∼500 kDa), two dynein intermediate chains (DIC ∼74 kDa), two light intermediate chains (DLIC ∼33–59 kDa), and several dimers of light chains (DLC/LC7/roadblock, LC8, and TcTex1 ∼10–14 kDa)."
Entered by Uri M
ID 112204