Step size of molecular motor

Range dynein 4-32nm: myosin VI 21-51nm nm
Organism Eukaryotes
Reference Gennerich A, Vale RD. Walking the walk: how kinesin and dynein coordinate their steps. Curr Opin Cell Biol. 2009 Feb21(1):59-67. doi: 10.1016/ p.60 right column 2nd paragraph & p.64 right column 2nd paragraphPubMed ID19179063
Primary Source R.S. Rock, S.E. Rice, A.L. Wells, T.J. Purcell, J.A. Spudich, H.L. Sweeney Myosin VI is a processive motor with a large step size Proc Natl Acad Sci U S A, 98 (2001), pp. 13655–13659PubMed ID11707568
Comments P.60 right column 2nd paragraph:"Single-molecule studies suggest that dynein walks in a hand-over-hand-like fashion (Figure 2b), although its stepping behavior and directionality are more irregular than kinesin's [refs 6, 7, 8 and 9••]. Evidence has shown that dynein advances via coordination of its two motor domains [refs 8 and 32], but the details of cytoplasmic dynein's step size, stall force, and directionality remain controversial [refs 6, 7, 8, 9•• and 33]. Observations of variable step sizes (4–32 nm) and directionality suggest a considerable diffusional component to its step, making dynein stepping more akin to that of myosin VI (21–51 nm) [primary source] than kinesin."
Entered by Uri M
ID 112205