| Range |
1.00E-05 - 1.00E-04 chromosome loss per generation
|
| Organism |
Yeast |
| Reference |
Santaguida, S., & Amon, A. (2015). Short-and long-term effects of chromosome mis-segregation and aneuploidy. Nature Reviews Molecular Cell Biology, 16(8), 473-485. doi: 10.1038/nrm4025. p.475 right column bottom paragraphPubMed ID26204159
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| Primary Source |
[19] Sears, D. D., Hegemann, J. H. & Hieter, P. Meiotic recombination and segregation of human-derived artificial chromosomes in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA 89, 5296–5300 (1992). [20] Hartwell, L. H. & Smith, D. Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics 110, 381–395 (1985). [21] Brown, M. et al. Fidelity of mitotic chromosome transmission. Cold Spring Harb. Symp. Quant. Biol. 56, 359–365 (1991). [22] Storchova, Z. et al. Genome-wide genetic analysis of polyploidy in yeast. Nature 443, 541–547 (2006).PubMed ID1608938, 3894160, 1819497, 17024086
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| Method |
Primary source [19] abstract: "[Investigators] have developed a system that utilizes human DNA-derived yeast artificial chromosomes (YACs) as marker chromosomes to study factors that contribute to the fidelity of meiotic chromosome transmission. Since aneuploidy for the YACs does not affect spore viability, different classes of meiotic missegregation can be scored accurately in four-viable-spore tetrads including precocious sister separation, meiosis I nondisjunction, meiotic chromatid loss, and meiosis II nondisjunction." |
| Comments |
P.475 right column bottom paragraph:"Given the profound adverse effects of aneuploidy on human health, it is not surprising that cells with an unbalanced karyotype are rare. In budding and fission yeast, for example, the chromosome loss rate is estimated to be between 1 × 10^−5 and 1 × 10^−4 per generation [primary sources] (Table 1)." |
| Entered by |
Avigail |
| ID |
112099 |