| Value |
1
presynaptic terminal/4µm
|
| Organism |
Mouse Mus musculus |
| Reference |
Li L et al., Visualizing the distribution of synapses from individual neurons in the mouse brain. PLoS One. 2010 Jul 9 5(7):e11503. doi: 10.1371/journal.pone.0011503. p.7 left column bottom paragraphPubMed ID20634890
|
| Method |
Abstract:"[Investigators] present a new genetic synaptic labeling method that relies on expression of a presynaptic marker, synaptophysin-GFP (Syp-GFP) in individual neurons in vivo." |
| Comments |
p.6 left column bottom paragraph:"In the molecular layer, [investigators’] data show that on average 25 presynaptic terminals are found per 100µm along the ascending segments and the parallel fibers, or one presynaptic terminal for every 4µm (Figure 4D). This density is considerably higher than
previous estimates of one presynaptic terminal for every 6.8µm or 9.4µm along the parallel fibers or ascending segments, respectively, based on bouton counting along Golgi-stained granule cell axons in mice [PMID 16623829]. A likely explanation for this difference is that [investigators’] tracing method offers more sensitive detection of presynaptic terminals compared to previously used methods that rely on counting varicosities along axons as synapses [PMID 16623829]." For 1bouton/4µm dendrite in rat hippocampus neurons in vitro see Ziv 1996 PMID 8755481 p.96 right column top paragraph |
| Entered by |
Uri M |
| ID |
112026 |