Average cell volume

Range untreated cells 86±2: rapamycin treated cells 130±7 µm^3
Organism Budding yeast Saccharomyces cerevisiae
Reference Chan YH, Marshall WF. Organelle size scaling of the budding yeast vacuole is tuned by membrane trafficking rates. Biophys J. 2014 May 6 106(9):1986-96. doi: 10.1016/j.bpj.2014.03.014. p.1990 left column 3rd paragraphPubMed ID24806931
Method Abstract:"In this study, [investigators] measure the vacuole-cell size scaling trends in budding yeast using optical microscopy and a novel, to [their] knowledge, image analysis algorithm."
Comments p.1990 left column 2nd paragraph:"Thus, both the reported enlargement of the vacuole and the fusion of vacuoles seen in rapamycin-treated cells may be a natural consequence of scaling. To test this possibility, vacuole size was measured in cells that were treated with rapamycin for 4 h. Untreated cells have an average cell size of 86±2µm^3, and rapamycin treated cells arrest and grow to a larger average size of 130±7µm^3 (p < 0.0001, Student’s t-test)."
Entered by Uri M
ID 111978