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||"This value also sets a lower affinity limit of ~15kJ per mol for complex formation, as reflected in the thermodynamic data compiled by Olsson et al. [primary source]. These authors collected ITC [isothermal titration calorimetry] data for complexes containing ligands from natural biological sources and medicinal chemistry projects, and they plotted them on a diagram of ?H against -T?S (FIG. 1 BNID 111405)."