Fate of serine flux

Range 50.7% pyruvate: 6.5% cell biomass: 36.3% glycine synthesis: remainder for other metabolites % of serine
Organism Bacteria Escherichia coli
Reference Selvarasu S. et al., Characterizing Escherichia coli DH5alpha growth and metabolism in a complex medium using genome-scale flux analysis. Biotechnol Bioeng. 2009 Feb 15 102(3):923-34. doi: 10.1002/bit.22119. p.926 right column bottom paragraphPubMed ID18853410
Comments "While 50.7% of serine flux was directed towards pyruvate, 6.5% was used for cell biomass, 36.3% for glycine synthesis (1.22 mmol/gDCW/h) and the remaining for other metabolites (O-acetyl-L-serine and phosphatidylserine). The resulting flux distribution suggested that the majority of serine was assimilated for pyruvate production leading to acetate secretion."
Entered by Uri M
ID 111287