Mean velocity of DNA replication fork in keratinocyte

Value 1.46 kb/min Range: ±0.01 (0.14 - 11.8) Table - link kb/min
Organism Human Homo sapiens
Reference Conti C, Saccà B, Herrick J, Lalou C, Pommier Y, Bensimon A. Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells. Mol Biol Cell. 2007 Aug18(8):3059-67. p.3062 table 1 & right column top paragraphPubMed ID17522385
Method "[Researchers] examined human primary keratinocytes obtained from skin biopsies carried out on three different donors and grown with three different media conditions."
Comments "As shown in Figure 1D, measurements of IdU and CldU signals revealed a mean fork velocity of 1.46±0.01 kb/min (Table 1), in agreement with previous reports (Yurov, 1980 Jackson and Pombo, 1998). Noticeably, a large heterogeneity in fork velocity was also observed, with values ranging from 0.14 to 11.8 kb/min (panel in Figure 1D)." See notes beneath table
Entered by Uri M
ID 111200