Median inter origin DNA replication distance in keratinocyte

Value 111 kb Range: Table - link kb
Organism Human Homo sapiens
Reference Conti C, Saccà B, Herrick J, Lalou C, Pommier Y, Bensimon A. Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells. Mol Biol Cell. 2007 Aug18(8):3059-67. p.3061 right column bottom paragraph and fig.1C and p.3062 table 1PubMed ID17522385
Method "[Researchers] examined human primary keratinocytes obtained from skin biopsies carried out on three different donors and grown with three different media conditions."
Comments "To study the origin distribution and clustering, [researchers] focused on the interorigin distance. In normal keratinocytes, [researchers] measured and plotted more than 600 interorigin distances, resulting in a median value of 111 kb (Figure 1C), which is shorter than previous estimates (150–300 kb Yurov, 1980 Berezney et al., 2000 BNID 111193)."
Entered by Uri M
ID 111197