| Range |
2 - 9 (each replicon 100–200 kbp) replicons/focus
|
| Organism |
Mammals |
| Reference |
Conti C, Saccà B, Herrick J, Lalou C, Pommier Y, Bensimon A. Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells. Mol Biol Cell. 2007 Aug18(8):3059-67. p.3060 left column 2nd paragraphPubMed ID17522385
|
| Primary Source |
Huberman, J. A., and Riggs, A. D. (1968). On the mechanism of DNA replication in mammalian chromosomes. J. Mol. Biol. 32, 327–341. & Jackson, D. A., and Pombo, A. (1998). Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells. J. Cell Biol. 140, 1285–1295 & Berezney, R., Dubey, D. D., and Huberman, J. A. (2000). Heterogeneity of eukaryotic replicons, replicon clusters, and replication foci. Chromosoma 108, 471–484.PubMed ID5689363, 9508763, 10794569
|
| Comments |
"Characteristic replication patterns have been described for
different stages of the S-phase (Dimitrova and Gilbert, 1999
Dimitrova and Berezney, 2002). It has been also observed
that these replication foci display a typical nuclear distribution
and timing, which are maintained at subsequent cell
cycles (Leonhardt et al., 2000 Sadoni et al., 2004). Therefore,
these stable replication structures likely represent a fundamental
unit of chromatin organization, where replicons are
thought to cluster into functional domains formed by chromatin
loops. This spatial organization of replicons into clusters
seems to be of critical importance for the timely completion
of replication in higher eukaryotes. According to the
classical view of replicon clustering in mammalian nuclei,
each focus consists of 2–9 replicons of relatively small size
(100–200 kbp), which are equally spaced and simultaneously
duplicated in 45–60 min (primary sources)." |
| Entered by |
Uri M |
| ID |
111194 |