| Comments |
"In early Xenopus embryos, transcription is repressed
and DNA replication starts at nonspecific sites every 5–15
kb. The exit from midblastula and the beginning of transcription
reorganizes the spatio-temporal pattern of origin
firing, with replication occurring at specific sites every
150 –300 kb (Hyrien et al., 1995). In spite of this flexibility
in the distribution of active origins along the genome, the
total number of origins is a crucial parameter for the
efficient duplication of the genome (Machida et al., 2005
Shechter and Gautier, 2005)." |