| Range |
Table - link
|
| Organism |
Mouse Mus musculus |
| Reference |
Salpeter MM, Harris R. Distribution and turnover rate of acetylcholine receptors throughout the junction folds at a vertebrate neuromuscular junction. J Cell Biol. 1983 Jun96(6):1781-5. p.1783 table IIPubMed ID6853602
|
| Method |
"[Researchers] used innervated mouse sternomastoid muscle to examine
both the localization and turnover rate of junctional receptors
at the top thickened pjm [post junctional membrane] and at the bottom nonthickened
membrane. [Researchers] did this for the total population of receptors as
well as for receptors newly inserted at the junction during a 2-
d period. [They] found that the turnover rate of total and newly
inserted AChRs [Acetylcholine receptors] in both the top and bottom of the pjm are
within the range given by others for innervated junctional
AChR. [They] further found that there is no apparent preferential
localization of newly inserted receptors in the bottom vs. the
top of the folds. This suggests that during turnover of adult
junctional receptors there is a rapid equilibration of receptor
location to maintain a steady state throughout the entire membrane." |
| Comments |
"Fig. 1 illustrates an EM [electron microscopy] autoradiogram such as was used for
the analysis. Tables I and II and Fig. 2 give the receptor site
densities at the thickened pjm [post junctional membrane] and the bottom folds for total
receptors and for receptors newly inserted during a 2-d period.
Data are also given for the degradation of these newly inserted
receptors during a period of 6 d." See notes beneath table |
| Entered by |
Uri M |
| ID |
111078 |