| Value |
5E-05
cm/sec
Range: Table - link cm/sec
|
| Organism |
Generic |
| Reference |
Walter A, Gutknecht J. Permeability of small nonelectrolytes through lipid bilayer membranes. J Membr Biol. 1986 90(3):207-17. p.211 table 1PubMed ID3735402
|
| Primary Source |
Wolosin, J.M., Ginsburg, H. 1975. The permeation of organic acids through lecithin bilayers: Resemblance to diffusion in polymers, Biochim. Biophys. Acta 389 :20-33PubMed ID237547
|
| Method |
"Diffusion of small nonelectrolytes through planar lipid bilayer membranes (egg phosphatidylcholine-decane) was examined by correlating [least square regression analysis] the permeability coefficients of 22 solutes with their partition coefficients between water and four organic solvents." |
| Comments |
"If solute permeability through a lipid bilayer is governed
by the same forces that determine its partitioning
into nonaqueous solvents, then pm and Kp
should correlate. Figure 2 shows the relationships
between membrane permeability and partition coefficients
into (a) hexadecane, (b) olive oil, (c) octanol,
and (d) ether. The exact values of pm [membrane permeability] and Kp [partition coefficient]
are given in Table 1." |
| Entered by |
Uri M |
| ID |
110823 |