| Range |
at pH 6.0 +87mV: at pH 7.5 +11mV mV
|
| Organism |
Mouse Mus musculus |
| Reference |
Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature. 2006 Feb 9 439(7077):737-40. p.738 right column 3rd paragraph & p.739 fig.4bPubMed ID16467839
|
| Method |
"...by using a simple approach to patch-clamp spermatozoa
and to characterize whole-spermatozoan currents, [researchers] describe a
constitutively active flagellar calcium channel that is strongly
potentiated by intracellular alkalinization by using a simple approach to patch-clamp spermatozoa
and to characterize whole-spermatozoan currents, [they] describe a
constitutively active flagellar calcium channel that is strongly
potentiated by intracellular alkalinization." |
| Comments |
"The potential at which half
the channels are activated (V1/2) shifts (-76 mV, from +87 mV at
pH 6.0 to +11 mV at pH 7.5 (Fig. 4b))." |
| Entered by |
Uri M |
| ID |
110722 |