| Range |
young mice 4.8e-5 old mice 5.0e-5 mutant frequency (uncertain units ?)
|
| Organism |
Mouse Mus musculus |
| Reference |
Busuttil RA, Garcia AM, Reddick RL, Dollé ME, Calder RB, Nelson JF, Vijg J. Intra-organ variation in age-related mutation accumulation in the mouse. PLoS One. 2007 Sep 12 2(9):e876. p.1 left column 2nd paragraphPubMed ID17849005
|
| Primary Source |
Dolle´ ME, Giese H, Hopkins CL, Martus HJ, Hausdorff JM, et al. (1997) Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nat Genet 17: 431–434.PubMed ID9398844
|
| Method |
"Using transgenic mice harboring a chromosomally integrated
lacZ reporter gene" |
| Comments |
"Interestingly, the small intestine, a tissue with a very high cell
proliferative activity, was found to undergo the largest age-related
increase in mutant frequency among all organs studied, i.e., from
11.0X10^-5 in young mice to 25.6X10^-5 in old mice [BNID 110457]. By
contrast, in brain, a postmitotic organ, there was virtually no such
age-related increase, i.e., from 4.8X10^-5 in young animals to
5.0X10^-5 in old ones [primary source]." "age group: 3–8 months (young), 16–21 months (middle), and 25–34 months (old)." |
| Entered by |
Uri M |
| ID |
110458 |