Mutation rate per genome per replication

Value 0.49 mutation/genome/replication Range: Table - link mutation/genome/replication
Organism Mouse Mus musculus
Reference Drake JW, Charlesworth B, Charlesworth D, Crow JF. Rates of spontaneous mutation. Genetics. 1998 Apr148(4):1667-86. p.1673 Table 5PubMed ID9560386
Method Notice that this is per genome replication not per sexual generation
Comments "The mouse data come from the controls for the extensive radiation experiments performed at Oak Ridge, Harwell and Neuherberg, and summarized by Russell and Russell (1996). A total of 1,485,036 progeny harbored 69 visible mutations at seven loci for a rate of 6.6 × 10^-6 per locus per generation. In addition to the complete mutations, about 4.8 × 10^-5 mosaic mutations were detected at five loci these mutations tended to produce about 50% germ-line mosaicism, so that the adjusted mosaic rate is (4.8 × 10^-5)(0.5)/5 = 4.8 × 10^-6. Thus, the total mutation rate was about 1.1 × 10^-5 per locus per generation. Assuming 10^3 b per locus, we obtain 1.1 × 10^-8 mutations per b per generation. Finally, dividing by 62, the estimated number of cell divisions prior to a sperm (Drost and Lee 1995), gives µb = 1.8 × 10^-10 mutations per b per cell division. Taking G = 2.7 × 10^9 b (Laird 1971) and Ge as the amount of DNA required for 8 × 10^4 genes (Bird 1995) of length 10^3 bp generates the additional values listed in Table 5."
Entered by Ron Milo - Admin
ID 100320