| Range |
young mice 11e-5 old mice 25.6e-5 mutant frequency (uncertain units ?)
|
| Organism |
Mouse Mus musculus |
| Reference |
Busuttil RA, Garcia AM, Reddick RL, Dollé ME, Calder RB, Nelson JF, Vijg J. Intra-organ variation in age-related mutation accumulation in the mouse. PLoS One. 2007 Sep 12 2(9):e876. p.1 left column 2nd paragraphPubMed ID17849005
|
| Primary Source |
Dolle ´ME, Snyder WK, Gossen JA, Lohman PH, Vijg J (2000) Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Proc Natl Acad Sci U S A 97: 8403–8408.PubMed ID10900004
|
| Method |
"Using transgenic mice harboring a chromosomally integrated
lacZ reporter gene" |
| Comments |
"Interestingly, the small intestine, a tissue with a very high cell proliferative activity, was found to undergo the largest age-related increase in mutant frequency among all organs studied, i.e., from 11.0X10^-5 in young mice to 25.6X10^-5 in old mice [primary source]. By contrast, in brain, a postmitotic organ, there was virtually no such age-related increase, i.e., from 4.8X10^-5 in young animals to 5.0X10^-5 in old ones [BNID 110458]." "age group: 3–8 months (young), 16–21 months (middle), and 25–34 months (old)." |
| Entered by |
Uri M |
| ID |
110457 |