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Effects of mutations in TEM1 (beta-lactamase)

Range	~30% cause a partial reduction in fitness: ~62% have no immediate measurable effects on fitness % of mutations
Organism	bacteria
Reference	Soskine M, Tawfik DS. Mutational effects and the evolution of new protein functions. Nat Rev Genet. 2010 Aug11(8):572-82. doi: 10.1038/nrg2808. p.573 right column bottom paragraphPubMed ID20634811
Comments	"Approximately 30% of TEM1 mutations cause a partial reduction in fitness, primarily owing to mildly destabilizing mutations that reduce the levels of soluble, folded protein. The remaining fraction (~62%) has no immediate measurable effects on fitness (BOX 1). Although this detailed distribution is available for only one protein, experiments with other proteins show similar trends-approximately 40% of mutations reduce or completely abolish the activity of the mutated protein (Camps et al., 2007 PMID 17917869)."
Entered by	Uri M
ID	110450