| Range |
(Rif R) 0.33×10^−10 (Nal R) 0.21×10^−10 mutations/nucleotide/generation
|
| Organism |
Bacteria Escherichia coli |
| Reference |
Lee H, Popodi E, Tang H, Foster PL. Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing. Proc Natl Acad Sci U S A. 2012 Oct 9 109(41):E2774-83. doi: 10.1073/pnas.1210309109. p.E2775 left column bottom paragraph & p.E2776 table 2PubMed ID22991466
|
| Method |
Classical fluctuation tests |
| Comments |
"Table 2 gives mutation rates for the wild-type strain estimated using classical fluctuation tests, scoring for resistance to rifampicin (RifR) and to nalidixic acid (NalR). When normalized to the number of nucleotides that, when mutated, give the resistance phenotypes (PMID 12713816, PMID 22904280, PMID 3020376), the two mutation rates are 0.33 and 0.21×10^-10 mutations per nucleotide per generation, respectively." |
| Entered by |
Uri M |
| ID |
111340 |