| Value |
1e+11
B-cells/single individual’s lymphocyte population
|
| Organism |
Human Homo sapiens |
| Reference |
Glanville J, Zhai W, Berka J, Telman D, Huerta G, Mehta GR, et al. Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire. Proc Natl Acad Sci U S A 2009 106:20216-21. doi: 10.1073/pnas.0909775106. p.20216 left column bottom paragraphPubMed ID19875695
|
| Primary Source |
Perelson AS, Oster GF (1979) Theoretical studies of clonal selection: Minimal antibody repertoire size and reliability of self-non-self discrimination. J Theor Biol 81: 645–670. & Trepel F (1974) Number and distribution of lymphocytes in man. A critical analysis. Klin Wochenschrift 52: 511–515.PubMed ID94141, 4853392
|
| Comments |
"The
combinatorial association of such stochastically generated light and
heavy chains has the potential to generate many orders of magnitude more diversity than can be uniquely displayed on the 10^11
B-cells in a single individual’s lymphocyte population (primary sources)" |
| Entered by |
azim58 |
| ID |
110381 |