| Range |
mother ~15: 20-year-old father ~25: 40-year-old father ~65 mutations
|
| Organism |
Human Homo sapiens |
| Reference |
Kondrashov A. Genetics: The rate of human mutation. Nature. 2012 Aug 23 488(7412):467-8. doi: 10.1038/488467a. p.468 left column top paragraphPubMed ID22914161
|
| Primary Source |
[1] Kong et al., Rate of de novo mutations and the importance of father's age to disease risk. Nature. 2012 Aug 23 488(7412):471-5. doi: 10.1038/nature11396. [2] Keightley PD, Rates and fitness consequences of new mutations in humans. Genetics. 2012 Feb190(2):295-304. doi: 10.1534/genetics.111.134668.PubMed ID22914163, 22345605
|
| Method |
Primary source [1] abstract:"[Researchers] conduct a study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent-offspring trios at high coverage." |
| Comments |
P.467 right column bottom paragraph: "Kong and colleagues' study [primary source [1]] is by far the largest of its kind yet conducted, involving 78 Icelandic parent–offspring trios. Their estimate of 60 new mutations per generation is in agreement with previous calculations [primary source [2]], but their data also reveal that, although a 20-year-old father transmits, on average, approximately 25 mutations to his child, a 40-year-old father transmits around 65. This means that every additional year of paternal age results in an average of two extra mutations in human offspring. By contrast, the authors found that the number of de novo mutations transmitted by the mother is always roughly 15, regardless of her age." |
| Entered by |
Uri M |
| ID |
110295 |