| Value |
1.6
kb/min
Range: ±0.3 kb/min
|
| Organism |
Budding yeast Saccharomyces cerevisiae |
| Reference |
Sekedat MD, Fenyö D, Rogers RS, Tackett AJ, Aitchison JD, Chait BT. GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome. Mol Syst Biol. 2010 6: 353. doi: 10.1038/msb.2010.8 p.5 right column 2nd paragraphPubMed ID20212525
|
| Method |
"[Researchers] adopted a complementary approach for assaying replication dynamics using whole genome time-resolved chromatin immunoprecipitation combined with microarray analysis of the GINS complex, an integral member of the replication fork." |
| Comments |
"Once an active
origin fires, the GINS complex moves at an almost constant
rate of 1.6±0.3 kb/min. Its movement through the inter-origin
regions is consistent with that of a protein complex associated
with a smoothly moving replication fork. This progression rate
is considerably lower and more tightly distributed than those
inferred from previous genome-wide measurements assayed
through nascent DNA production (BNID 110149, 110150)." |
| Entered by |
Uri M |
| ID |
110151 |